Dr. Mohammad Zahid Ashraf

Head

Office Address:
Department of Biotechnology,
Jamia Millia Islamia (Central University),
New Delhi 110025

Administrative Responsibilities Inside University

  1. Director (Academics), JMI, New Delhi
  2. Institutional coordinator, MHRD-SPARC.
  3. External Member,  Research Council, University of Kashmir, J&K
  4. Chairman, Animal House Facility, JMI, New Delhi
  5. Chairman, Article Processing Committee, JMI, New Delhi
  6. Member, IPR and Patent Committee, JMI, New Delhi

Awards/Honors

Honors:

  1. Fellowship, National Academy of Sciences, Allahabad, 
  2. Fellowship, Indian Academy of Science, Bangalore
  3. Membership, Guha Research Conference, India
  4. Membership,  National Academy of Medical Sciences, India

Awards:

  1. Visitor Award (Biological Sciences), 2021
  2. Ramachandran National Bioscience Award, Department of Biotechnology, 2018
  3. Basanti Devi Amir Chand Award, Indian Council of Medical Research, 2018
  4. PA Kurup Oration, Indian Society for Atherosclerosis Research, 2014
  5. Surg. Rear Admiral M. S. Malhotra Awards, DRDO, 2014
  6. Innovations Award, Cleveland Clinic Foundation, USA, 2008

Other Recognitions:

  1. Member, Panel of Fats and Oil,  FSSAI, Govt. of India
  2. Member, Task Force on VTE, ICMR, Govt. of India
  3. Member, CTEP,  DBT, Govt. of India
  4. National coordinator, SPARC- India-Portugal collaborations, Govt. of India
  5. Member, Pharmacopeia Commission, Govt. of India
  6. Member,  Research Council, University of Kashmir, J&K
  7. Member, Board of Studies, Department of Zoology, AMU, Aligarh
  8. Member, Board of Studies, South Bihar Central University, Patna
  9. Invited Judge (2008) for Basic Science Poster Competitions of the American Heart Association’s Scientific Sessions New Orleans, USA
  10. Research Investigator (2007) Center for Stem Cell and Regenerative Medicine, National Center for Regenerative Medicine group, Case Western Reserve University and Cleveland Clinic Foundation, USA
  11. Investigator, Vascular Biology Working Group, sponsored by University of Florida College of Medicine, USA
  12. External Review, Distinguished Scientists Selection committee-2008, American Heart Association, US

Awards received by Research Scholars/Post-Doctoral Fellows

  1. Dr Aastha Mishra (DST-INSPIRE faculty working in our group)
    • SERB woman excellence award 2019
    • Young Investigator Award- International Society for Mountain Medicine 2018
  2. Dr Neha Gupta (Alumni- PhD student)
    • SERB woman excellence award 2019
    • INSA Young Scientist award 2018
    • DST-INSPIRE Faculty 2017
  3. Aatira Vijay (PhD student)
    • Early Career Investigator Award-American Heart Association 2019, Scientific Sessions in Philadelphia, Pennsylvania on November 16-18, 2019.
  4. Prabhash Kumar Jha (Alumni- PhD student)
    • 2019 Paul Dudley White International Scholar Award- American Heart Association, Basic Cardiovascular Science Scientific Sessions 2019 , Boston, Massachusetts, July 29 , 2019
  5. Swati Sharma (Alumni- PhD student) 
    • 2019 Young Investigator Award, Indian Society for Atherosclerosis Research.

Education, Training & Experience

2001

Ph.D. in Biosciences, Delhi University & JMI, Delhi

(Thesis title: Endothelial dysfunction during experimentally induced atherosclerosis)

1996

Masters in Biosciences, JMI, New Delhi

1994

Bachelors in Biosciences, JMI, New Delhi

2001-2006

Postdoctoral Research Fellow, Dept. of Cell Biology, Lerner Research Instt.

Cleveland Clinic, OH, USA

2006-2009

Postdoctoral Research Fellow, Dept. of Cell Biology, Lerner Research Instt.

Cleveland Clinic, OH, USA

2009-2017

Scientist D & Group Head, Genomics Division Defence Institute of Physiology and Allied Sciences, DRDO, Delhi

2014-2017

Scientist E & Group Head, Genomics Division Defence Institute of

Physiology and Allied Sciences, DRDO, Delhi

2017-Present

Professor, Department of Biotechnology JMI, New Delhi

2020-Present

Head, Department of Biotechnology JMI, New Delhi

International Collaborations

  1. Prof. Girish M Shah, Laval University, Canada. Role of Poly(ADP-ribose) Polymerase-1 (PARP1) in Hypoxia-induced Thrombosis. Shastri Institutional Indo-Canadian Collaborative Research Grant.
  2. Dr Manavendra Singh, National University Singapore. Effect of Hypoxia on tissue factor mediated coagulation pathway and their function in hypoxia induced thromboembolism. SPARC-MHRD. 

Lab Members

Dr. Armiya Sultan

(Postodoctral Fellow)

Email: asultan@jmi.ac.in

Dr. Swati Sharma

(Postodoctral Fellow)

Email: sswat.me@gmail.com

Shankar Chanchal

(CSIR-SRF)

Ph.D. Scholar: 2017-Present

Email: schanchal123@gmail.com

Raishal Safdar

(SRF)

Ph.D. Scholar: 2017- Present

Email: raishalsafdar@gmail.com

Syed Mohd

(CSIR-SRF)

Ph.D. Scholar: 2018-Present

Email: mahmudaga@gmail.com

Dr. Mohammed Yasir

(AYUSH SRF)

Ph.D. Scholar:

Email: yasirm7@gmail.com

Khan Sadia

(CSIR-JRF)

Ph.D. Scholar: 2019-Present

Email: sksadia08@gmail.com

Mohd. Yasir Khan

(CSIR-JRF)

Ph.D. Scholar: 2021- Present

Email: kyasir027@gmail.com

Previous Lab members

Dr. Aastha Mishra

(DST-Inspire Faculty)

Email: aastha0602@gmail.com

Senior Scientist: CSIR IGIB

https://www.igib.res.in/?q=AasthaMishra

Memberships & activities in Scientific and Professional Activities

  1. Invited Member Pulmonary Vascular Research Institute, UK
  2. Executive Council, Indian Society for Atherosclerosis Research,
  3. Life Member, Indian Society for Atherosclerosis Research
  4. Life Member, International Atherosclerotic Society
  5. Life Member, International Society for Heart Research (India Chapter)
  6. Life Member, International Academy of Cardiovascular Sciences
  7. Life Member, Indian Society for Hematology & Transfusion Medicine
  8. Member, Society for Vascular Medicine and Biology
  9. Member, North American Vascular Biology Organization
  10. Member, American Heart Association (2003-2009)

Editorial /Reviewer Roles for Scientific Journals:

  1. Blood
  2. Blood Advances
  3. International Journal of Hematology Research
  4. Frontiers in Chemical Sciences
  5. Journal Of Thrombosis & Haemostasis
  6. Thrombosis Research
  7. High Altitude Medicine & Biology
  8. Scientific Reports
  9. American Journal of Hypertension
  10. Journal of Hypertension
  11. PLoS ONE
  12. International Journal of Biochemistry & Cell Biology
  13. Pharmaceutical Biology
  14. Human Toxicology
  15. Microbes & Infection

Photo Gallery

Cardiovascular Genomics laboratory:

Research Overview

Dr. Ashraf has focused his research that was of urgent need and challenge for nation and scientific community to elucidate the blood clotting problem inflicting our soldiers that are positioned at high altitude defending our borders. He remains a pioneer in the field of high altitude thrombosis and has done seminal work in resolving the mystery of blood clotting on exposure to hypoxia.

Amongst the major outcomes of his translational research, the landmark work was internationally recognized and published in prominent journal ‘Blood’ in 2014, received accolade by an Editorial. The study revealed a novel cause for blood clot formation at altitudes and proposed ‘Calpain’ as a novel biomarker (IPO: 733/DEL/2014) for early diagnosis; thereby providing timely diagnosis to Indian Army Jawans posted at Siachen Glaciers defending our borders.

Dr. Ashraf study has contributed enormously in understanding the etiopathology of clot formation at altitudes, for the development of possible drug targets. He elucidated previously unknown cause of thrombosis at altitudes is centrally regulated by a complex network of coagulatory and NLRP3-inflammasome mediated inflammatory responses. His research established (PNAS, 2017) that, hypoxia-inducible Factor-(HIF)-1α, (Nobel prize for Medicine 2019) a protein complex plays an integral role in the body's response to low-oxygen, activates an inflammatory complex inflammasome-NLRP3 and releases inflammatory cytokines like IL-18 and IL-1β, which eventually causes blood clotting. This novel finding was highly recognized worldwide and published in the ‘PNAS’ in 2017; also proposed as potential therapy (Nature India- doi:10.1038/nindia.2017.143). The Inflammation-Coagulation-Hypoxemia convolutions has also been observed in COVID-19 pathogenesis, low-molecular-weight heparin have shown encouraging results, therefore natural compund based anticoagulant are also being explore.

In a rare breakthrough, his lab developed a microRNAs mimic based therapy against thrombosis; for the first time the antithrombotic potential of microRNAs was established.  These preclinical findings were validated in human patients, supporting the translational significance of miR-145 for development of a novel antithrombotics (IPO:1398/DEL/2015), which could be also tested against COVID-19 infection also. These findings were published in EBiomedince (2017), a recently established journal in collaboration with Cell and Lancet.

Dr. Ashraf was the key investigator for one of the biggest longitudinally prospective cohort study carried out by Indian Army and DRDO, involving 1000 infantry Indian Army soldier towards their deployment to Siachen Glaciers. His extensive research established the incidence of thrombosis at altitudes were inferentially higher and resulted in convincible recommendation for Indian Army during operational deployment. He has also established his leadership qualities by carrying out a multicentric-cross-sectional study on thrombosis involving Army Hospital RR Delhi, Command Hospital Chandimandir, AFMC Pune and DRDO. He has applied this finding on people staying at high altitude regions including native highlanders.  Dr. Ashraf’s ability to translate his research findings for societal benefit has added new dimensions in the field of high altitude research. The high altitude research contributions were attested by his participation in International consortium for revision of Acute Mountain Sickness diagnosis guidelines.

Research Projects

  1. Investigating the role of Hypoxia Inducible Factors-1a (HIF-1α) and NLRP3 Inflammasome axis in Pre-Eclampsia during Pregnancy. National Bioscience Award-Grant, Department of Biotechnology. (2019-2022)- 15 Lakhs.
  2. Effect of Hypoxia on tissue factor mediated coagulation pathway and their function in hypoxia induced thromboembolism. SPARK-MHRD (International Collaboration with National University of Singapore). (2018-2020)-57 Lakhs.
  3. Determination of antithrombotic potential of traditionally used Unani formulations. AYUSH, Govt of India. (2018-2021)-58 Lakhs.
  4. Role of Poly(ADP-ribose) Polymerase-1 (PARP1) in Hypoxia-induced Thrombosis. Shastri Institutional Indo-Canadian Collaborative Research. (2018-2021)- 10 lakhs.
  5. Vitamin D level at HA is Attributable to Higher Incidence of Thrombosis at High Altitude and the Role of NLRP3 Inflammasome. Department of Biotechnology. (2019-2022)-60 Lakhs.
  6. Search for novel anti-platelet and anti-thrombin peptides from Indian viper venom (Daboiarusselii): Purification, characterization and evaluation of its antithrombotic potential. Department of Biotechnology (North East Region programme). (2018-2021)- 20 Lakhs.
  7. Characterizing Milk Colostrum of Ladakhi Cows and Yak for Identification of Biomolecules with Therapeutic Potential. DST (ASACODER Program); Multicentric project: NDDRI Karnal, IISc, Bangalore; DRDO, Leh and JMI. (2020-2023)- 40Lakhs.
  8. The long noncoding RNA (lncRNA) Landscape of hypoxia induced thrombosis. SERB, DST. (2019-2022)- 55 lakhs.
  9. Identification of Biomarkers for High Altitude Induced Thromboembolic Disorders and screening of Natural Compounds for Antithrombotic Potential. (2014-2019)- 532 lakhs.
  10. High Altitude induced thromboembolic disorders. (2009-2014)- 493 lakhs.
  11. Platelet proteomic analysis in animals exposed to high altitude simulated conditions. (2009-2010)- 10 Lakhs.

Research Publications, Reviews & Book Chapters

Citations: 4669
H- Index: 37
i10- Index: 101

Patents:

  1. A Novel Approach to Cardiovascular Disease Treatment and Diagnosis. US and world Patent Pending: Filed with Cleveland Clinic Innovations in Cardiovascular Medicine.
  2. A Method of Risk Assessment of Clot Formation (733/DEL/2014).
  3. Specific Small Single Stranded RNA Molecules With Antithrombotic Properties And Uses Thereof (1398/DEL/2015).

Research publications:

  1. Jha PK, Vijay A, Prabhakar A, Chatterjee T, Nair V, Bajaj N, Kumar B, Sharma M, Ashraf MZ. Transcriptome Profiling Reveals the Endogenous Sponging Role of LINC00659 and UST-AS1 in High-Altitude Induced Thrombosis. Thromb Haemost. 2021 Nov; 121(11):1497-1511. doi: 10.1055/a-1390-1713. Epub 2021 Feb 12.
  2. Mishra A, Ashraf MZ. Response: Comment and Update on "Using Artificial Intelligence to Manage Thrombosis Research, Diagnosis, and Clinical Management". .Semin Thromb Hemost. 2021 Feb; 47(1):115-116. doi: 10.1055/s-0040-1721755. Epub 2021 Feb 1.
  3. Mishra A, Chanchal S, Ashraf MZ. Host-Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis. TH Open. 2020 Dec 17; 4(4):e403-e412. doi: 10.1055/s-0040-1721706. eCollection 2020 Oct.PMID: 33354650
  4. Masih D, Tripathi JK, Rakhra G, Vats A, Verma SK, Jha PK, Sharma M, Ashraf MZ, Singh SN.Deciphering Biochemical and Molecular Signatures Associated with Obesity in Context of Metabolic Health. Genes (Basel). 2021 Feb 19; 12(2):290. doi: 10.3390/genes12020290.
  5. Detao Gao,  Mohammad Z. AshrafLifang ZhangNiladri S. KarTatiana V. Byzova and Eugene A. Podrez, Cross-linking modifications of HDL apoproteins by oxidized phospholipids: Structural characterization, in vivo detection, and functional implications Journal of Biological Chemistry, 2020doi: 10.1074/jbc.RA119.008445
  6. Prabhakar A, Chatterjee T, Bajaj N, Tyagi T, Sahu A, Gupta N, Kumari B, Nair V, Kumar B, Ashraf MZ. Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains. Blood Advances. 2019 Nov 26; 3(22):3713-3723.
  7. Mohammad S, Mishra A, Ashraf MZ. Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis. Biomolecules. 2019 Oct 24; 9(11). pii: E649.
  8. Mishra A, Ashraf MZ. Using Artificial Intelligence to Manage Thrombosis Research, Diagnosis, and Clinical Management.  Semin Thromb Hemost. 2019 Sep 28. doi: 10.1055/s-0039-1697949.
  9. Neha Gupta,  Manish Sharma,  Tathagata Chatterjee,  Tarun Tyagi,  Anita Sahu1,  Amit Prabhakar,  Mohammad Zahid Ashraf. Activation of NLRP3 Inflammasome Complex Regulates the Onset of Hypoxia Induced Thrombosis, Arteriosclerosis, Thrombosis, and Vascular Biology. 2015; 35, A605 [Impact Factor-8.1]
  10. Rakhra G, Masih D, Vats A, Vijay A, Ashraf MZ, Singh SN.  Study of Metal-Metal Interactions and Their Biomarkers Using an Intestinal Human Cell Line. Biol Trace Elem Res. 2019 Aug 31. doi: 10.1007/s12011-019-01831-2
  11. Vijay A, Garg I, Ashraf MZ. Perspective: DNA Copy Number Variations in Cardiovascular Diseases. Epigenet Insights. 2018 Dec 12; 11: 2516865718818839.
  12. Prabhash K Jha , Aatira VijayAmit Prabhakar, Tathagat Chatterjee, Nitin Bajaj, Velu Nair, Bhuvnesh Kumar, Mohammad Z Ashraf, Manish Sharma The Long Noncoding RNA Landscape of the High Altitude Induced Thromboembolic Disorder: Role of Endogenous miRNA Sponge Circulation Research. 2019;125:A653 [Impact factor-15.2]
  13. Aatira Vijay, Prabhash K Jha, Seema Parveen, Shailendra Goel, Amit Prabhakar, Bhuvnesh Kumar, Tathagat Chatterjee, Nitin Bajaj, Velu Nair, Manish Sharma,  Mohammad Z Ashraf. Aberrant Promoter Hypermethylation Mediated Regulation of Thrombomodulin Gene in High Altitude Induced Deep Vein Thrombosis, Circulation. 2019; 140:A10076
  14. Jha, P. K., A. Sahu, A. Prabhakar, T. Tyagi, T. Chatterjee, P. Arvind, J. Nair, Mohammad Zahid Ashraf.. "Genome-Wide Expression Analysis Suggests Hypoxia-Triggered Hyper-Coagulation Leading to Venous Thrombosis at High Altitude." Thromb Haemost 2018; 118, no. 7: 1279-95.
  15. Brij BhushanA.Prabhakar, A.P.Yadav, M.Z.Ashraf S.B.SighL.Ganju, Activation of platelets and inflammatory cytokines in male participants of an Indian Antarctic expedition, Polar Science, 2019, (19), 146-150
  16. Aatira Vijay, Prabhash Kumar Jha, Iti Garg, Manish Sharma, Mohammad Zahid Ashraf andBhuvnesh Kumar. micro-RNAs dependent regulation of DNMT and HIF1a gene expression in thrombotic disorders. Scientific Reports 2019;20;9(1):4815
  17. Anita Sahu, Prabhash Kumar Jha, Prabhakar AChatterjee TTyagi TKumari BKhan NNair VAshraf MZ, MicroRNA-145 impedes thrombus formation via targeting tissue factor in venous thrombosis- EBio Medicine. 2017 Dec; 26:175-186.
  18. Ahmad I, Sharma S, Gupta N, Rashid Q, AbidM, Ashraf MZ, Jairajpuri MA. Antithrombotic potential of esculin 7, -O-pentasulfate (EPS) for its role in thrombus reduction using rat thrombosis model. International Journal of Biology of Macromolecules. 2018; 119: 360-368. ISSN: 0141-8130
  19. Lake Louise AMS Score Consensus Committee, Eric Achatz, Edi Albert, Jon S. Andrews, James D. Anholm, Mohammad Zahid Ashraf, Paul Auerbach, Buddha Basnyat, Beth A. …. The 2018 Lake Louise Acute Mountain Sickness Score. High Altitude Medicine Biology 2018 Mar; 19(1):4-6.
  20. Gupta NSahu APrabhakar AChatterjee TTyagi TKumari BKhan NNair VBajaj NSharma MAshraf MZ. Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proceedings of National Academy of Sciences – USA  2017:  114(18):4763-4768.
  21. Yanamandra U, Singh SP, Yanamandra S, Mulajkar D, Grewal RS, Singh S, Ashraf MZ, Reddy P, Nair V. Endothelial markers in high altitude induced systemic hypertension (HASH) at moderate high altitude. Med J Armed Forces India. (2017)  73(4):363-369.
  22. Jha PK, Vijay A, Sahu A, Ashraf MZ. Comprehensive Gene expression meta-analysis and integrated bioinformatic approaches reveal shared signatures between thrombosis and myeloproliferative disorders. Scientific Reports 2016 Nov 28; 6:37099. doi: 10.1038/srep37099.
  23. Sharma S, Garg I, Ashraf MZ., TLR signalling and association of TLR polymorphism with cardiovascular diseases. Vascul Pharmacol. 2016 Dec; 87:30-37.
  24. Kumari B, Prabhakar A, Sahu A, Chatterjee T, Tyagi T, Gupta N, Nair V, Ashraf MZ. Endothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population. Clin Appl Thromb Hemost. 2016 Aug 1
  25. Ashraf MZ. Hypertension at high altitude: the interplay between genetic and biochemical factors in the setting of oxidative stress. Hypertension Research. 2016 Apr; 39(4):199-200.
  26. Neha GuptaManish SharmaTathagata ChatterjeeTarun TyagiAnita Sahu1Amit PrabhakarMohammad Zahid Ashraf. Activation of NLRP3 Inflammasome Complex Regulates the Onset of Hypoxia Induced Thrombosis, Arteriosclerosis, Thrombosis, and Vascular Biology. 2015; 35, A605
  27. Tarun Tyagi, Amit Prabhakar, Shantanu Sengupta and Mohammad Z Ashraf.  A Novel Role of Protein Disulfide Isomerase in Calpain Regulated Hypoxia Induced Prothrombotic Phenotype,  2014; Blood: 124 (21)
  28. Kumari B, Srivastava S, Chatterjee T, Vardhan R, Tyagi T, Gupta N, Sahu A, Chandra K, Ashraf MZ. Study of associated genetic variants in Indian subjects reveals the basis of ethnicity related differences in susceptibility to venous thromboembolism. Thrombosis., 182762. Epub 2014 Sep 30. 2014
  29. Qudsia RashidMohammad AbidNeha GuptaTarun Tyagi,  M. Zahid Ashraf,  M. Aman Jairajpuri,  Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action, BioMed Research International  ID 630482, Epub 28 August 2014.
  30. Tarun Tyagi, Shadab Ahmad, Neha Gupta, Yasmin Ahmad, Shantanu Sengupta, M. Zahid Ashraf, Altered expression of platelet proteins mediate hypoxia induced prothrombotic phenotype: Calpain playing a major role? Blood, 20; 123(8):1250-60. 2014.
  31. Chatterjee T, Gupta N, Choudhry VP, Behari M, Saxena R, Ashraf MZ.  Prediction of ischemic stroke in young Indians: is thrombophilia profiling a way out? Blood Coagulation & Fibrinolysis.  24(4):449-53. 2013
  32. Ashraf MZ, Anita Sahu, Implication of scavenger receptors in atherothrombotic disorders. Biomolecular Concepts, Volume 3, Issue 4, Pages 371–380, 2012  Cover page article
  33. Gupta N. Ashraf MZ, Exposure to High Altitude: A Risk Factor for Venous Thromboembolism? Seminars in Thrombosis and Hemostasis; 38(2):156-63. 2012,
  34. Swati Srivastava, Shuchi Bhagi1, Babita Kumari, Khem Chandra, Soma Sarkar, Mohammad Z. Ashraf Association of polymorphism in angiotensin and aldosterone synthase genes of renin-angiotensin-aldosterone (RAAS) system with HAPE. J Renin Angiotensin Aldosterone Syst. Mar; 13(1):155-60. 2012
  35. Ashraf MZ, Gupta N., Scavenger Receptors: Implications in Atherothrombotic Disorders. International Journal of Biochemistry & Cell Biology. 43(5):697-700. 2011  
  36. Yi Ma, Mohammad Z. Ashraf, and Eugene A. Podrez Scavenger receptor BI plays a dual role in platelet reactivity and thrombosis, Blood. 16; 116(11):1932-412010
  37. Jianzhong Shen, Unni M. Chandrasekharan, Mohammad Z. Ashraf, Eric Long, Richard E. Morton, Yusen Liu, Jonathan D. Smith, Paul E. DiCorleto, Lack of MAP Kinase Phosphatase-1 Protects ApoE-null Mice against Atherosclerosis. Circulation Research. 19; 106(5):902-10. 2010
  38. Mohammad Z. Ashraf*, Detao Gao*, De Lin, Lawrence M. Sayre, Eugene A. Podrez. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. *equal contribution, Journal of Biological Chemistry 12; 285(7):4447-54. 2010
  39. Mohammad Z. Ashraf, Niladri S. Kar, Eugene A. Podrez. Oxidized phospholipids: Biomarker for cardiovascular diseases, International Journal of Biochemistry & Cell Biology, 41(6):1241-4. 2009
  40. Mohammad Z. Ashraf, Niladri Kar, Robert G. Salomon, Maria Febbraio and Eugene A. Podrez Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI SR-BI Mediated Specific Uptake of Cholesteryl Esters, Journal of Biological Chemistry. 18;283(16):10408-14, 2008  
  41. Niladri S. Kar, Mohammad Z Ashraf, Manojkumar Valiyaveettil and Eugene A. Podrez Mapping and Characterization of Oxidized Low-Density Lipoprotein and OxPCCD36 Binding Site of Scavenging Receptor CD36, Journal of Biological Chemistry. 28;283(13):8765-71, 2008   
  42. Valiyaveettil M, Ashraf MZ*, Kar N*, Byzova TV, Febbraio M, Podrez EA. Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI. Blood. 15; 111(4):1962-71. 2008 * equal contribution
  43. Bandyopadhyay S, Ashraf MZ, Daher P, Howe PH, DiCorleto PE. HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. Molecular and Cellular Biology, 27(12):  4207-4216, 2007.     
  44. Ashraf MZ, Hussain ME, Fahim M, Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: restoration of endothelial function in rats.  Life Sciences, 77: 837-857, 2005.
  45. Ashraf M. Z., Hussian M.E. and Fahim M., Endothelium mediated vasorelaxant effect of garlic in isolated rat aorta: Role of nitric oxide.  Journal of Ethanopharmacology 90(1):5-9, 2004.

Book Chapters:

  1. Swati Sharma, Aastha Mishra, M. Zahid Ashraf,  Involvement of Epigenetic Control and Non-coding RNAs in Cardiovascular System, Book title “Non-coding RNAs in Cardiovascular Diseases”  SPRINGER NATURE PUBLICATIONS
  2. Neha Gupta, Mohammad Zahid Ashraf. Hypoxia Signaling in Cardiovascular Diseases, “Hypoxia Signaling in Cardiovascular Diseases, Hypoxia and Anoxia”. DOI:10.5772/intechopen.80456. by Intech-International Publication Group, 2018.

Swati Srivastava, Ashraf MZ, Oxidized Phospholipids: Introduction & Biological Significance” in the forthcoming book “LIPOPROTEIN” ISBN 980-953-307-145-4 by Intech-International Publication Group, 2012.